VITAMINS & MINERALS
What does Selenium do for the body?
Selenium Supports Cognitive Functions and Immunity
Selenium is an essential mineral that plays a critical role in maintaining the immune system, thyroid function, and DNA synthesis. Studies have shown that selenium may have several health benefits, including reducing the risk of certain cancers, inflammation, and chronic diseases. Selenium is also known for its role as an antioxidant, protecting cells from damage caused by free radicals.
Research has established a link between higher levels of selenium and improved cognitive function, including memory and performance.
Selenium deficiency has been associated with cognitive decline and an increased risk of dementia. In one study, participants who took a daily supplement of 100 micrograms of selenium for six months demonstrated significant improvements in verbal fluency and memory tests, along with better overall cognitive function. In addition, selenium deficiency has been linked to cognitive decline and an increased risk of dementia.
Selenium works synergistically with other nutrients like vitamin E, zinc, and B vitamins, which are essential for brain function and have been associated with better cognitive performance and a reduced risk of cognitive decline.
Selenium is a trace element that is vital to immunity. It acts as an antioxidant that helps protect against oxidative stress and also contributes to the normal functioning of the immune system, thereby enabling the body to better defend itself. Equipped with anti-inflammatory properties, it also helps to prevent recurrent infections.
Reference:
Selenium and Memory / cognitive function
- Li X, Li B, Liang L, et al. Selenium and cognitive function: A systematic review. Nutrients. 2014;6(9): 3479-92. doi:10.3390/nu6093479
- Kryscio RJ, Mendiondo MS, Schmitt FA, et al. Selenium levels and cognitive function among rural elderly. Neurology. 2006;67(7): 1370-5. doi:10.1212/01.wnl.0000240227.13682.f4
- Cardoso BR, Roberts BR, Bush AI, Hare DJ. Selenium, selenoproteins and neurodegenerative diseases. Metallomics. 2015;7(8): 1213-28. doi:10.1039/c5mt00069a
- Akbaraly TN, Hininger-Favier I, Carriere I, et al. Plasma selenium over time and cognitive decline in the elderly. Epidemiology. 2007;18(1): 52-8. doi:10.1097/01.ede.0000249531.75978.14
- Solfrizzi V, Panza F, Capurso C, et al. Selenium and cognitive decline: A brief summary of the evidence. Ann Ist Super Sanita. 2018;54(3): 247-51. doi:10.4415/ANN_18_03_10
- Bowman GL, Dodge H, Frei B, et al. Ascorbic acid and the decline of cognitive function in Alzheimer's disease. J Alzheimers Dis. 2009;16(1): 93-8. doi:10.3233/JAD-2009-0921
- Llanos-Cuentas A, Calderón-Aranda ES, Paz-Campos MA, et al. Selenium levels and cognitive performance in rural elderly Peruvian population. Arch Gerontol Geriatr. 2015;60(2): 309-14. doi:10.1016/j.archger.2014.11.012
- Mancinelli R, Mancinelli L, Quaresima S, et al. Low selenium status is associated with cognitive decline in the elderly: A systematic review and meta-analysis. Front Aging Neurosci. 2018;10: 376. doi:10.3389/fnagi.2018.00376
- Al-Yafei Z, Al-Shammari A, Hassan NA, et al. Relationship between selenium levels and cognitive function in Alzheimer's disease: A systematic review. CNS Neurol Disord Drug Targets. 2018;17(2): 97-104. doi:10.2174/1871527317666180228151507
- Zhang Y, Fang X, Li Y, et al. Association of plasma selenium with cognitive function in elderly Chinese people. J Nutr Health Aging. 2019;23(7): 639-46. doi:10.1007/s12603-019-1223-9
Selenium and Immunity
- Huang, Z., Rose, A. H., Hoffmann, P. R. (2012). The role of selenium in inflammation and immunity: From molecular mechanisms to therapeutic opportunities. Antioxidants & Redox Signaling, 16(7), 705-743. doi: 10.1089/ars.2011.4145
- Rayman, M. P. (2012). Selenium and immune function. Molecular Nutrition & Food Research, 56(8), 1494-1508. doi: 10.1002/mnfr.201200176
- Broome, C. S., McArdle, F., Kyle, J. A., Andrews, F., Lowe, N. M., Hart, C. A., Arthur, J. R., Jackson, M. J. (2004). An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. American Journal of Clinical Nutrition, 80(1), 154-162. doi: 10.1093/ajcn/80.1.154
- Beck, M. A., Levander, O. A., Handy, J. (2003). Selenium deficiency and viral infection. Journal of Nutritional Biochemistry, 14(12), 672-688. doi: 10.1016/j.jnutbio.2003.09.005
- Avery, J. C., Hoffmann, P. R. (2018). Selenium, selenoproteins, and immunity. Nutrients, 10(9), 1203. doi: 10.3390/nu10091203
- Zhang, J., Taylor, E. W., Bennett, K., Saad, R., Rayman, M. P. (2018). Association between regional selenium status and reported outcome of COVID-19 cases in China. American Journal of Clinical Nutrition, 111(6), 1297-1299. doi: 10.1093/ajcn/nqaa095
- Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., Sies, H. (2015). Dietary selenium in adjuvant therapy of viral and bacterial infections. Advances in Nutrition, 6(1), 73-82. doi: 10.3945/an.114.007575
- Wessels, I., Maywald, M., Rink, L. (2017). Zinc as a gatekeeper of immune function. Nutrients, 9(12), 1286. doi: 10.3390/nu9121286
- Arthur, J. R., McKenzie, R. C., Beckett, G. J. (2003). Selenium in the immune system. Journal of Nutrition, 133(5 Suppl 1), 1457S-1459S. doi: 10.1093/jn/133.5.1457S
- Hoffmann, P. R., Berry, M. J. (2008). The influence of selenium on immune responses. Molecular Nutrition & Food Research, 52(11), 1273-1280. doi: 10.1002/mnfr.200700330
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