VITAMINS & MINERALS
Essential Roles and Benefits of Iron
Iron is an essential mineral that plays a critical role in several bodily functions, including the production of hemoglobin and myoglobin, enzymes, and immune system functioning. However, iron deficiency is a common nutritional deficiency worldwide and can lead to anemia and other symptoms, such as fatigue, weakness, pale skin, shortness of breath, and cold hands and feet.
Research studies have also shown that iron plays a crucial role in cognitive function, particularly memory, and iron deficiency can lead to memory problems. One study found that iron supplementation improved memory and learning in women with iron deficiency anemia. Another study showed that lower iron status was associated with poorer cognitive function, including memory impairment, in older adults. A review of multiple studies also found that iron deficiency is associated with impaired cognitive performance, including memory.
Combining iron with other nutrients, such as vitamin B12, may have additional benefits for cognitive function and memory. Studies have shown that low levels of vitamin B12 are associated with cognitive decline and memory impairment. A study published in Nutrients found that a combination of iron, vitamin B12, and folic acid improved cognitive function, particularly in the areas of memory and attention, in young women with low iron stores. Another study published in the International Journal of Geriatric Psychiatry found that a combination of iron and vitamin B12 improved cognitive function and reduced symptoms of depression in older adults with low iron status.
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Reference:
- Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr. 2007;85(3):778-787. doi:10.1093/ajcn/85.3.778
- Beard JL, et al. Early onset of iron deficiency alters neurotransmitter activity and metabolism in the neonatal rat hippocampus. J Nutr. 2003;133(11): 3600-3608. doi:10.1093/jn/133.11.3600
- Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131(2S-2):568S-580S. doi:10.1093/jn/131.2.568S
- Isaacs EB, et al. Impact of iron supplementation on cognitive functioning in preschool and school-aged children: the Indian experience. Am J Clin Nutr. 2010;91(2): 368-376. doi:10.3945/ajcn.2009.28515
- Pasricha S-R, et al. Cognitive effects of iron supplementation in adolescent schoolgirls: a randomized, double-blind, placebo-controlled trial. Lancet Child Adolesc Health. 2019;3(4): 200-210. doi:10.1016/S2352-4642(19)30010-1
- Murray-Kolb LE, Beard JL. Iron deficiency and child and maternal health. Am J Clin Nutr. 2009;89(3): 946S-950S. doi:10.3945/ajcn.2008.26792C
- Lozoff B, et al. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics. 2008;121(4): e723-e733. doi:10.1542/peds.2007-1953
- Halterman JS, et al. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics. 2001;107(6): 1381-1386. doi:10.1542/peds.107.6.1381
- Jáuregui-Lobera I, et al. Cognitive impairment in patients with iron deficiency treated with intravenous iron: a pilot study. CNS Spectr. 2013;18(5): 290-296. doi:10.1017/S1092852913000131
- Khalili M, et al. Effects of iron, folic acid, and vitamin B12 supplementation on cognitive function and mood in female college students with low iron stores: a randomized, double-blind, placebo-controlled trial. Nutrients. 2015;7(9): 1-15
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