VITAMINS & MINERALS
What is Folic Acid good for?
Vitamin B9, also known as folic acid or folate, is a vital water-soluble vitamin that plays an essential role in several significant functions in the body. It supports the creation and maintenance of new cells and is necessary for the production of DNA and RNA. Deficiency in B9 vitamin can cause a range of health issues, including anemia, fatigue, weakness, irritability, and even depression. B9 vitamin is especially important during periods of rapid growth, such as during pregnancy or childhood, where it plays a crucial role in fetal development, reduces the risk of neural tube defects, and supports the creation of red blood cells. In addition, B9 vitamin has been linked to reducing the risk of cardiovascular disease, supporting mental health, helping prevent cancer, and aiding digestive health.
B9 vitamin has also been associated with cognitive function and memory, particularly in older adults. Studies have shown that B9 vitamin may improve cognitive function and memory, including aspects such as processing speed and executive function. Higher intake of B9 vitamin has been linked to better memory performance in older adults, and it may also have a protective effect against Alzheimer's disease. B9 vitamin deficiency has been linked to an increased risk of depression, which can affect cognitive function and memory.
La vitamine B9 a également été associée à la fonction cognitive et à la mémoire, en particulier chez les personnes âgées. Des études ont montré que cette vitamine peut améliorer la fonction cognitive et la mémoire, y compris sur des aspects tels que la vitesse de traitement et la fonction exécutive. Un apport plus élevé en vitamine B9 a été associé à une meilleure performance de la mémoire chez les personnes âgées, et il peut également avoir un effet protecteur contre la maladie d'Alzheimer. La carence en vitamine B9 a été associée à un risque accru de dépression, qui peut affecter les fonctions cognitives et la mémoire.
Reference:
Memory and Cognitive Function
- Tiemeier H, van Tuijl HR, Hofman A, et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry. 2002;159(12): 2099-2101. doi:10.1176/appi.ajp.159.12.2099
- Sánchez-Villegas A, Doreste J, Schlatter J, et al. Association between folate, vitamin B(6) and vitamin B(12) intake and depression in the SUN cohort study. J Hum Nutr Diet. 2009;22(2):122-133. doi:10.1111/j.1365-277X.2008.00935.x
- Gilbody S, Lightfoot T, Sheldon T. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health. 2007;61(7):631-637. doi:10.1136/jech.2006.050385
- Murakami K, Mizoue T, Sasaki S, et al. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition. 2008;24(2):140-147. doi:10.1016/j.nut.2007.10.013
- Lewis SJ, Lawlor DA, Davey Smith G, et al. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol Psychiatry. 2006;11(4):352-360. doi:10.1038/sj.mp.4001790
- Morris MS, Fava M, Jacques PF, et al. Depression and folate status in the US Population. Psychother Psychosom. 2003;72(2):80-87. doi:10.1159/000068687
- Coppen A, Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial. J Affect Disord. 2000;60(2):121-130. doi:10.1016/s0165-0327(99)00139-0
- Alpert JE, Mischoulon D, Nierenberg AA, et al. Folinic acid (Leucovorin) as an adjunctive treatment for SSRI-refractory depression. Ann Clin Psychiatry. 2002;14(1):33-38. doi:10.3109/10401230209147182
- Delle Chiaie R, Pancheri P, Scapicchio P. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002;76(5):1172S-1176S. doi:10.1093/ajcn/76/5.1172S
- Papakostas, G. I., Petersen, T., Mischoulon, D., Ryan, J. L., Nierenberg, A. A., Bottiglieri, T., Rosenbaum, J. F., Alpert, J. E., & Fava, M. (2004). Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. Journal of Clinical Psychiatry, 65(8), 1090-1095.
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